Hepatocellular carcinoma (HCC) presents a significant problem that necessitates a greater understanding of its underlying molecular complexity in order to improve diagnostics and therapies. Recent studies have shed light on the critical role that mitochondrial dysfunction plays in the development and course of HCC. Once thought to be primarily involved in the synthesis of cellular energy, mitochondria are now known to be key participants in the regulation of a variety of cellular functions that go beyond bioenergetics. The purpose of this (...) review is to elucidate the diagnostic and therapeutic implications of mitochondrial dysfunction in HCC by synthesising ideas from conventional and contemporary scientific literature. Within diagnostics, the discovery of mitochondrial biomarkers such as mutations in mitochondrial DNA and abnormalities in respiratory chain complex activities provides a state-of-the-art viewpoint for the timely identification and accurate description of HCC. In addition, non-invasive imaging methods that focus on mitochondrial function offer prospective means of improving clinical diagnostic accuracy. Moving on to treatment, a growing area of study investigates how mitochondria-targeted therapies might be used to treat HCC. Novel substances and repurposed medications with the potential to induce selective apoptosis in cancer cells, reduce oxidative stress, and restore mitochondrial homeostasis are highly promising. In the fight against hepatocellular carcinoma, an understanding of the complex interactions between mitochondrial dysfunction and HCC opens new diagnostic opportunities and paves the way for individualised treatment plans. (shrink)

Type 2 diabetes mellitus (T2DM) is a multifaceted chronic condition characterized by insulin resistance and hyperglycemia. This review synthesizes evidence on the influence of lifestyle factors such as diet, physical activity, and stress on the development and progression of T2DM. It highlights the intricate relationship between obesity, insulin resistance, and β-cell dysfunction, with a particular focus on the role of psychological stress in exacerbating disease outcomes. Through the analysis of recent studies, the review explores how lifestyle interventions, including dietary changes, (...) exercise, and stress management, can improve glycemic control and reduce complications. This comprehensive review underscores the need for integrated, personalized management strategies in T2DM care, emphasizing the importance of addressing both physiological and psychological factors to optimize outcomes and prevent complications. (shrink)

Saudi Arabia has had remarkable progress in reducing maternal and neonatal mortality over the past decades. While various challenges persist, such as unequal access to healthcare, a history of pre-existing maternal conditions, and neonatal complications, this review will focus on critical determinants of maternal and neonatal outcomes in Saudi Arabia, including government-driven efforts through Vision 2030 towards enhancing health care infrastructure and policies. The focus has been on antenatal care, neonatal intensive care units, and maternal mortality audit issues, enhancing outcomes. (...) Recommendations are the adoption of standardized risk assessment tools and health disparities abatement between the Saudi population and non-Saudi populations. Future strategies encompass holistic approaches: education, infrastructure improvements, and policy frameworks, aiming to achieve international standards. (shrink)

The University of Michigan conference “Where Religion, Policy, and Bioethics Meet: An Interdisciplinary Conference on Islamic Bioethics and End-of-Life Care” in April 2011 addressed the issue of brain death as the prototype for a discourse that would reflect the emergence of Islamic bioethics as a formal field of study. In considering the issue of brain death, various Muslim legal experts have raised concerns over the lack of certainty in the scientific criteria as applied to the definition and diagnosis of brain (...) death by the medical community. In contrast, the medical community at large has not required absolute certainty in its process, but has sought to eliminate doubt through cumulative diagnostic modalities and supportive scientific evidence. This has recently become a principal model, with increased interest in data analysis and evidence-based medicine with the intent to analyze and ultimately improve outcomes. Islamic law has also long employed a systematic methodology with the goal of eliminating doubt from rulings regarding the question of certainty. While ample criticism of the scientific criteria of brain death (Harvard criteria) by traditional legal sources now exists, an analysis of the legal process in assessing brain death, geared toward informing the clinician’s perspective on the issue, is lacking. In this article, we explore the role of certainty in the diagnostic modalities used to establish diagnoses of brain death in current medical practice. We further examine the Islamic jurisprudential approach vis-à-vis the concept of certainty (yaqīn). Finally, we contrast the two at times divergent philosophies and consider what each perspective may contribute to the global discourse on brain death, understanding that the interdependence that exists between the theological, juridical, ethical, and medical/scientific fields necessitates an open discussion and active collaboration between all parties. We hope that this article serves to continue the discourse that was successfully begun by this initial interdisciplinary endeavor at the University of Michigan. (shrink)

This paper unravels an unprecedented interplay between board gender diversity (BGD) and corporate environmental, social, and governance (ESG) disputes among Chinese A-share-listed nonfinancial companies from 2017 to 2021. Framed within a knowledge-based and sensemaking perspective of institutional frameworks, the research not only illuminates the profound impact of internal (corporate governance ratings) and external (regional institutional development) institutional factors on this intricate relationship but also brings to light a paradigm-shifting revelation. The study employed a diverse set of empirical tests, ranging from (...) ordinary least squares regression to advanced methods such as the generalized method of moments, two-stage least squares, and propensity score matching, providing a nuanced and comprehensive analysis. The findings highlight the pivotal role of female directors in significantly mitigating ESG disputes. A mechanism analysis further uncovers that internal and external institutional quality are potent positive moderators in shaping the BGD–ESG dispute dynamic. This research has profound implications, providing valuable insights for stakeholders, policymakers, and scholars, offering a comprehensive understanding of how gender diversity fosters sustainability while unravelling the intricate tapestry of internal and external institutional dynamics that shape ESG outcomes. (shrink)

Despite the obvious link between spirituality, religiosity and ethical judgment, a definition for the nature of this relationship remains elusive due to conceptual and methodological limitations. To address these, we propose an integrative Spiritual-based model derived from categories presumed to be universal across religions and cultural contexts, to guide future business ethics research on religiosity. This article aims to empirically test in the context of Islam. It examines how different Muslims' views of God influence their ethical judgments in organizations, and (...) how this process is mediated by their religious practice and knowledge. Comprising focus group and vignette designs, the study was carried out with a random sample of 427 executives and management professionals from Saudi. After data collection, the study hypotheses were tested using structural equation modeling. The findings confirmed that a view of God based on hope might be more closely associated with unethical judgments than a view based on fear or one balancing hope and fear. Furthermore, religious practice and knowledge were found to mediate the relationship between Muslims' different views of God and their ethical judgments. These results provide unique theoretical insights into religiosity's influence on ethical judgment, with important implications for management. (shrink)

Purpose. Nietzschean proponents classify people into seemingly two distinct groups: those possessing 'Master' moralities and those with 'Slave' moralities. Each type of person is characterized to have certain qualities, traits, ideologies, and methods of dealing with everyday situations. This paper attributes these moralities to the personnel working in the corporate sector of Pakistan to observe their prospects of success. Originality. A specialized survey instrument was designed to gauge different Morality Types of the study subjects by calculating a Morality Quotient. The (...) respondents were then categorized into three categories possessing, Slave, Master and Neutral or Mixed traits. These traits are then contrasted to the position held by the subjects to see which morality type was more prevalent in higher management levels and whether the association was significant. Conclusions. Our results prove to be contradictory to common wisdom and shows that despite the leadership-like qualities of those with Master moralities, the proportion of those with Slave moralities was significantly higher at senior management levels of the corporate sector in Pakistan. Moreover, a trend of declining Master morality traits is observed with the rise in managerial level. In addition, an association between work experience and Morality type was also observed indicating adaptability of cross morality traits with increasing job experience. These findings are in line with the increasing focus on democratic and adaptable leadership instead of autocratic leadership styles in contemporary organizations. (shrink)

This paper discusses how it is possible to find, in the Islamic tradition, a universal concept of “humanity”. It insists on the concept of “ummah” as a peculiar Muslim way to define a comprehensive humanity, and try to point out its internal limits. It shows the communal implication of this concept and the ways it can, or cannot, be considered as constitutive of a we-group concept that may eventually lead to conflict and violence. It brings to the attention of the (...) reader some historical examples, focusing, among others, on Mohammad Iqbal’s contribution. (shrink)

One of the consequences of Al-Qaeda’s terrorism has been its blurring of the distinction between national and international politics, both of which have lost a great deal of their former autonomy by serving as hosts for a set of new global concerns and practices. The Global War on Terror can be seen as an effort to externalize Al-Qaeda’s global threat by internationalizing it in a conventional war, and thus reinforcing both the autonomy of international politics and its separation from that (...) of a national variety. More than a conservative move to protect the international order, however, the War on Terror was also an ambitious attempt to remake global politics in the wake of the Cold War. But despite the transformations it has wrought, the War on Terror failed to create either a new global order or even a new global politics. (shrink)

Transcendental Ego is the principle of principles that philosophization of great philosophers such as Husserl has been based upon it. Husserl, too, as a follower of Descartes meditations and philosophy with attemption in intentionality of transcendental ego accepts it as the base of principles of philosophization and declares himself as a New Cartesian. In this study, the author develops an original reading of the Cartesian Meditation. This text, far from giving rise to a “Transcendental solipsism”, leads to a constitution of (...) intersubjectivity on various levels (“primordial”, “Intersubjective” et “Objective”). In its center, a “Phenomenological Construction” operates, i.e. a methodological piece that masters the genetic approach of intersubjectivity. Closely following the “almost mathematical” rigour of this crucial text of Husserl’s phenomenology, in this way equally tackles the issue of the constitution of the experience of the other and the truly intersubjective structure of transcendental subjectivity. This study concludes with the metaphysical results of the analysis of the experience of the other. (shrink)

In this article, I offer a reassessment of the influence of two disparate bodies of thought – republicanism and existentialism – on Hannah Arendt. Arendt, I argue, is not involved in an ‘agonistic appropriation’ of Heidegger. Arendt identifies two opposed attitudes in Heidegger’s work. The first Promethean moment places Heidegger squarely in the tradition of Western political philosophy, and the second seemingly correcting for this recommends a quietism. Arendt rejects both these attitudes. Machiavelli rather than Heidegger, I argue, is the (...) key influence on Arendt's political thought. Through a reading of Arendt’s published works and her unpublished 1955 lecture notes on Machiavelli I show that the central categories of Arendt’s thought emerge from her meditation on Machiavelli’s texts. Arendt finds in Machiavelli a performative understanding of politics, an accurate understanding of the connection between morality and politics, and a primacy given to politics that she thought it deserves. (shrink)

Famously posed by seventeenth-century French philosopher René Descartes, the mind–body problem remains unresolved in western philosophy and science, with both disciplines unable to move convincingly beyond the dualistic model. The persistence of dualism calls for a reframing of the problem through interdisciplinary modes of inquiry that include non-western points of view. One such perspective is Islamic theology of the soul, which, while approaching the problem from a distinct point of view, also adopts a position commensurate with dualism. Using this point (...) of convergence as a conceptual starting point, we argue that bringing into dialogue contemporary neuroscientific, philosophy of mind, and Sunni Islamic theological discourses may provide a fruitful way of reframing the age-old mind–body problem. This paper provides an overview of how these three discourses have approached the issue of the mind–body problem. Juxtaposing these three discourses, we hope, may ignite further scholarly di... (shrink)

The ability to initiate DNA replication is a critical step in the proliferation of all organisms. In bacteria, this process is mediated by an ATP‐dependent replication initiator protein, DnaA, which recognizes and melts replication origin (oriC) elements. Despite decades of biochemical and structural work, a mechanistic understanding of how DnaA recognizes and unwinds oriC has remained enigmatic. A recent study by Pelliciari et al. provides important new structural insights into how DnaA from Bacillus subtilis recognizes and processes its cognate oriC, (...) showing how DnaA uses sequence features encoded in the origin to engage melted DNA. Comparison of the DnaA‐oriC structure with archaeal/eukaryl replication origin complexes based on Orc‐family proteins reveals a high degree of similarity in origin engagement by initiators from di domains of life, despite fundamental differences in origin melting mechanisms. These findings provide valuable insights into bacterial replication initiation and highlight the intriguing evolutionary history of this fundamental biological process. (shrink)

Pediatric dentists rely on access to hospital operating rooms for safe, effective, and humane delivery of dental care. The children who benefit most from dental treatment in a hospital operating room are those who are very young, have dental anxieties or phobias, are precommunicative or noncommunicative, need extensive or invasive dental treatments, or have special healthcare needs. Diminishing access to hospital operating rooms for pediatric dental treatment has become an escalating problem in contemporary times. Financial barriers, hospital costs, reimbursement rates, (...) health insurance policies and deductibles, out-of-network hospitals, socioeconomic factors, and the COVID-19 pandemic are prominent contributing factors. This problem in access to care has resulted in long waiting times for hospital operating rooms, deferral of medically necessary dental care, and pain and infection among this vulnerable patient population. Pediatric dentists have responded to the problem by utilizing alternative methods of care delivery, such as in-office deep sedation or in-office general anesthesia, and by implementing aggressive medical management of dental caries. However, the youngest of pediatric patients and children with special healthcare needs still remain at a disadvantage in receiving definitive dental treatment. This article aims to highlight the ethical challenges faced by pediatric dentists in contemporary practice in the face of limitations in hospital operating room access through four case scenarios. (shrink)

Building on the notion that organizations are congruence seeking systems, this study investigates the impact of green investing on corporate environmental violations (CEVs). The research sample consists of China's A-share-listed companies for the period 2009–2020. The study employs a robust analytical framework that integrates least squares dummy variable approach, different proxies for regressors and moderators, and instrumental variable technique. Based on the rigorous methods, empirical analysis reveals that green investing helps mitigate CEVs, aligning with the theoretical premise of environmental strategic (...) congruence. The moderating results indicate that elevated CEO ability and a higher proportion of female directors on boards enhances strategic congruence and amplifies the alleviating effects of green investing on CEVs. Furthermore, cross-sectional analysis suggests that the mitigating effect of green investing on CEVs is more pronounced for firms in sensitive sectors, state-owned, and lacking internal controls for environmental, health, and safety. This research contributes nuanced insights on the role of strategic congruence in sustainable finance and governance and presents practical implications for policymakers, managers, and corporate leaders navigating the intricate landscape of environmental responsibility within an emerging market. (shrink)

What is the conceptual status of modernity in the Muslim world? Scholars describe Muslim attempts at appropriating this European idea as being either derivative or incomplete, with a few calling for multiple modernities to allow modern Islam some autonomy. Such approaches are critical of the apologetic way in which Muslims have grappled with the idea of modernity, the purity and autonomy of the concept of which is apparently compromised by its derivative and incomplete appropriation. None have attended to the conceptual (...) status of this apologetic itself, though it is certainly the most important element in Muslim debates on the modern. This essay considers the adoption of modernity as an idea among Muslim intellectuals in nineteenth-century India, a place in which some of the earliest and most influential debates on Islam's modernity occurred. It argues that Muslim apologetics created a modernity whose rejection of purity and autonomy permitted it a distinctive conceptual form. (shrink)

Kidney transplantation is the most efficacious and cost-effective treatment for end-stage renal disease. However, the treatment’s accessibility is limited by a chronic shortage of transplantable kidneys, resulting in the death of numerous patients worldwide as they wait for a kidney to become available. Despite the implementation of various measures the disparity between supply and needs continues to grow. This paper begins with a look at the current treatment options, including various sources of transplantable kidneys, for end-stage renal disease. We propose, (...) in accordance with others, the introduction of compensated kidney donation as a means of addressing the current shortage. We briefly outline some of the advantages of this proposal, and then turn to examine several of the ethical arguments usually marshaled against it in a bid to demonstrate that this proposal indeed passes the ethics test. Using available data of public opinions on compensated donation, we illustrate that public support for such a program would be adequate enough that we can realistically eliminate the transplant waiting list if compensation is introduced. We urge a pragmatic approach going forward; altruism in living kidney donation is important, but altruism only is an unsuccessful doctrine. (shrink)

The problem of adolescent girls escaping from homes is one of the social problems and phenomena alien to all societies, Arabic in particular, the Iraqi society known for its ancient traditions and family cohesion, and according to the significant changes witnessed by those societies, including Iraqi society, these changes led to the emergence of many deviant phenomena among the most affected youth, resulting in high rates of deviation and the spread of new subcultures that did not exist before that reject (...) conservative family values and create new values that try to adapt to These rapid changes and we find that adolescent girls are often affected by them, as we see a lot of teenage girls between the values of the conservative family and the values of the new subculture that calls for rebellion against parental authority and disobedience to their orders and escape from home, so escape has become a ghost that threatens many safe and stable homes and brings them sadness and shame, as it has become difficult for the family to forget, The fact that escape leads to immediate and long-term risks, the immediate risks of homelessness and social disintegration and long-term involvement in crime and drug addiction, especially those who are in their teens (10_18) as they aim at the unknown as a result of which it is necessary to study the social and psychological effects that can have a profound impact on the feet of adolescent girls to escape from homes and leave the family, which has profound effects not only on the family but on society as a whole. (shrink)

This paper attempts to reconsider the nature and function of the ‘spiritual’ dimension in literary texts and in literary study in the context of the present state of the discipline of literary studies. The present era is often defined as a ‘post-secular’ era, one in which themes of spirituality and mysticism are increasingly noticeable in literary works. The paper argues that to maintain its relevance to contemporary writers and readers, literary criticism has to address these themes in a concrete and (...) effective way. The paper recommends a comparative approach to the discussion of spirituality and mysticism in contemporary literature and literary criticism. In order to carry effective analytical potential, this approach, the paper emphasizes, has to be developed from specific spiritual traditions. The paper first discusses the disciplinary crisis literary studies have always been exposed to since their inception as a discipline of study in academic institutes. It then reviews the current state of the discipline and describes how the discipline came to be dominated by scientific and social approaches. Finally, it suggests the reinstitutionof the ‘spiritual’ element in literary study as a way out from the state of crisis in the discipline of literary studies. The paper thus attempts to strengthen the disciplinary identify of literary studies while exploring interdisciplinary aspects of the study literature. (shrink)

Education for sustainable development aims to develop students' awareness of sustainability issues and foster their attitudes towards environmental, economic, and social sustainability. The study aimed to identify the role of Prince Sattam bin Abdulaziz University in promoting environmental sustainability among its students, in line with Saudi Arabia's Vision 2030. A descriptive analytical approach was used, with a sample of 341 university students. The study found that faculty members ranked first in promoting sustainability, followed by curricula, student activities, and university administration. (...) The most important ways to activate the university's role in promoting sustainability from students' perspectives were rated as very important. Statistically significant differences were found between the sample's responses, with females expressing more support in university administration. Academic specialization also influenced responses, with scientific specializations showing more favor in university administration, faculty members, and curricula. The researchers made several recommendations based on the findings. (shrink)

Internet of Things-based environments pose various challenges due to their anytime/anywhere computing, and the efficient cryptographic based key management is one of the major challenges in Internet of Things. The key management life cycle consists of initialization, key generation, key registration, key backup, key update, key recovery, and key revocation. Our contribution in this paper is to summarize the state-of-the-art key management schemes and techniques in different scenarios, such as mobile ad hoc networks, wireless sensor networks, and the Internet of (...) Things environments. Further different issues related specifically to the Internet of Things environment are discussed and the causes and effects pertaining to the security breach for Internet of Things are identified. Furthermore, in this research work, we develop a novel permutation of threshold and identity-based key management schemes for the Internet of Things environment and have proposed future directions to counteract the attacks on confidentiality, integrity, authentication, and availability of security services in the Internet of Things environment and identified the two key management schemes, that is, identity and threshold schemes for Internet of Things, to resolve Internet of Things key management issues and maximum possible security services effective implementation. We evaluate our scheme with the help of mathematical and statistical techniques. (shrink)

Eksistensi Gambar dalam film menurut Gilles Deleuze adalah kehidupan manusia dan perjalanannya menyatu dengan Tuhan. Ketika manusia menyaksikan film pikirannya tertuju pada objek gambar- gambar yang bergerak sehingga dirinya ikut bersatu dengan realitas yang ada pada film. Otak manusia seperti layar film yang mampu menyingkap realitas dan pikiran manusia mulai tenggelam dan menyatu dengan alam semesta, karena otak manusia mengeluarkan elektron yang bermuatan negatif dari atom-atom kemudian elektron tersebut tertarik dan mengikuti gerakan dari gambar-gambar yang ada di film yang bermuatan (...) positif sehingga munculnya energi listrik dan gelombang, frekuensi cahaya yang mengakibatkan manusia mengalami pencapaian spiritual. Tujuan dari artikel ini adalah untuk membuktikan bahwa segala sesuatu di dunia ini mengalami perubahan dan ketidakpastian sedangkan eksistensi manusia di di dunia ini adalah tidak ada. Di dunia ini yang ada hanya energi dan hukum perubahan alam semesta. Hal itu dikarenakan manusia sudah menyatu dengan Tuhan dan alam semesta. Manusia yang sudah mengalami pencerahan memanifestasikan dirinya dengan mengimajinasikan semua hal tentang kehidupan dunia fisiknya. Dengan demikian, kehidupan di dunia adalah sebuah alam imajinasi atau pikiran saja. Penelitian ini menggunakan pendekatan deskriptif analitis dan metode deskriptif kuantitatif yang bersifat saintifik dengan mengintegralkan aspek kesenian, filsafat, mistisisme, spiritualisme, fisika klasik, fisika kuantum, mekanika kuantum dan kimia kuantum. Kesimpulan dari tulisan ini adalah manusia mengalami pencerahan dan mengalami perubahan forma atau bentuk dianalisa secara spiritual dan saintifik serta dapat memanifestasikan dan mengaktualisasikan aspek spiritualitasnya dalam bentuk materialisme di berbagai bidang disiplin ilmu seperti politik, ekonomi, geopolitik, kesenian, teknologi, sains, psikologi, agama dan budaya. Dengan demikian, manusia yang sudah tercerahkan dan mengalir energi alam semesta di dalam dirinya menjadi sebuah mesin atau alat pembangkit listrik bertenaga energi spiritual yang termanifestasikan dan terealisasi di dunia fisik. (shrink)

This current study aims to examine the importance of anesthesia for humans. Secondly, what are the types of anesthesia currently used in operations, and what is the role of anesthesia in preserving human life. A questionnaire was prepared via Google Drive and distributed to residents aged 25-55 years, men and women, in the city of Mecca. As for the questionnaire, it was distributed via the social media program (WhatsApp) for the purpose of distancing for fear of the presence of the (...) Corona virus. 380 questionnaires were distributed, and 370 responses were obtained via email to the main researcher. it concluded that requires continuing to work on continuous on advanced anesthesia methods. (shrink)

Introduction There is a paramount need for moral development for pharmacists and pharmacy students to practice the patient-centered profession. We aimed to explore the current situational judgment utilizing ethical reasoning among undergraduate pharmacy students. Methods A set of ten ethical dilemmas, representing potential real-life situations that the students come across in the university and may face in the future as a pharmacist were developed by a team of students, academic staff, and stakeholders. These ethical dilemmas were validated, checked for accuracy, (...) and piloted. An online questionnaire was created consisting of these ten scenarios as open-ended questions and administered to fourth year and fifth year PharmD students in a public university located at the city of Mecca, Saudi Arabia, asking them how they would react in that situation. Responses of the participants were analyzed using thematic analysis independently by four researchers and inter-rater agreement were achieved through consensus. Results Out of 205, 186 students completed the questionnaire with a response rate of 90.7%. Analysis and resulted in the generation of 32 codes, which were then categorized into seven overarching themes: student engagement, social and professional responsibility, academic integrity, legal obligation, moral obligation, signposting, and moral engagement and patient safety. Conclusions Undergraduate pharmacy students experience complex state of mind in connection with ethical reasoning. The participants’ situational judgment were driven by cultural norm, authority, and responsibility. Student engagement is also affected by the state of mind and feelings of mutual trust, perceived cultural influence and peer pressure. The students were prone to seek help from university administrators or teachers when faced with situations in which they were helpless. (shrink)

A system of system’s ability to function is derived from the integration of systems from different sources. An SOS’s systems serve two purposes: first, to accomplish their own specific aims, and second, to provide resources to the SOS as a whole. In the last few decades, machine learning and data analytics have been widely used in system design and acquisitions. Every organisation that acquires a sophisticated system employs some type of data analytics to evaluate the system’s independent objectives, which is (...) universally accepted. Data analytics and decision-making regarding the independent system is rarely shared across SOS stakeholders, even though the systems contribute to and benefit from the larger SOS. The goal of this research is to determine how the exchange of data sets and the corresponding analytics by SOS stakeholders can improve SOS capacity. Predicting SOS capabilities by exchanging relevant data sets and prescribing information connections between systems, we propose to use machine learning techniques. This article serves as an intermediate analysis of the above research work and aims to estimate the benefit of information sharing among the SOS stakeholders. In this research, we have applied different machine learning models to the IBM HR analytics data set to determine the corresponding analytics by SOS stakeholders that can improve SOS capacity. We propose using machine learning techniques to forecast SOS capabilities through the sharing of relevant data sets, and we prescribe the information linkages across systems to make this possible. This paper provides an update on the progress being made toward the aforementioned research project, and its primary focus is on developing a method to put a dollar amount on the benefits of information sharing among the many parties involved in the SOS. (shrink)

During the initial phases of the COVID-19 pandemic, stress and anxiety were pervasive among the masses due to high morbidity and mortality. Besides the fear of coronavirus was also particularly driven by social media. Many people started to look for faith and spiritual connections to gain comfort. The role of spiritual ties and religious beliefs in relation to coping with pandemic stress gained the attention of researchers in some parts of the world. This cross-sectional survey aimed at assessing the intensity (...) of stress and anxiety symptoms experienced by people and how much they were alleviated by employing spiritual connections. The study sample comprises 795 respondents with 52% males and 48% females living in Saudi Arabia. The brief online study questionnaire collected data about background variables, anxiety and stress scale from DASS-21, and items from the WHOQOL instrument assessed the use of spiritual beliefs to cope. Multiple regression models were tested to determine the role of spiritual connections after adjusting demographic variables. Results illustrated that after adjusting for gender and age, participants' anxiety symptoms decreased by units with each unit increase in the use of spiritual connections, and participants’ stress symptoms reduce by units with each unit increase in coping with spirituality. Additionally, females’ risk to experience anxiety and stress symptoms was more than males and, respectively. An increase in age decreases the likelihood of experiencing anxiety symptoms and stress symptoms by and units respectively. Findings support the protective role of spiritual connections despite small beta coefficients. The social and cultural context in Saudi Arabia favors deep-rooted connections with spirituality and faith. Our findings support that the reliance on spiritual connections helped older people to deal with exaggerated fear during the initial phase of the COVID-19 pandemic and reduces the risk of experiencing anxiety and stress symptoms. Females and younger participants were relatively vulnerable to developing these symptoms. We discussed these findings considering some recent studies that reported similar relationships and made recommendations for future research. (shrink)

Shared decision-making has become a new focus of health policy. Though its core elements are largely agreed upon, there is little consensus regarding which outcomes to prioritize for policy-mandated shared decision-making.

Abstract:Diagnostic classification systems in psychiatry have continued to rely on clinical phenomenology, despite limitations inherent in that approach. In view of these limitations and recent progress in neuroscience, the National Institute of Mental Health (NIMH) has initiated the Research Domain Criteria (RDoC) project to develop a more neuroscientifically based system of characterizing and classifying psychiatric disorders. The RDoC initiative aims to transform psychiatry into an integrative science of psychopathology in which mental illnesses will be defined as involving putative dysfunctions in (...) neural nodes and networks. However, conceptual, methodological, neuroethical, and social issues inherent in and/or derived from the use of RDoC need to be addressed before any attempt is made to implement their use in clinical psychiatry. This article describes current progress in RDoC; defines key technical, neuroethical, and social issues generated by RDoC adoption and use; and posits key questions that must be addressed and resolved if RDoC are to be employed for psychiatric diagnoses and therapeutics. Specifically, we posit that objectivization of complex mental phenomena may raise ethical questions about autonomy, the value of subjective experience, what constitutes normality, what constitutes a disorder, and what represents a treatment, enablement, and/or enhancement. Ethical issues may also arise from the (mis)use of biomarkers and phenotypes in predicting and treating mental disorders, and what such definitions, predictions, and interventions portend for concepts and views of sickness, criminality, professional competency, and social functioning. Given these issues, we offer that a preparatory neuroethical framework is required to define and guide the ways in which RDoC-oriented research can—and arguably should—be utilized in clinical psychiatry, and perhaps more broadly, in the social sphere. (shrink)

Numerous scholars have taken the popular stance against Roman emperor Nero’s actions. In the style of fictional narrative, this article argues for the defense of Nero against the widely held opinion. The article is written under the guise of Seneca, his tutor and advisor. It is written in the genre of biography and in the format of a letter addressed to Cassius Dio.

In developing countries, the patriarchal social construct, unsatisfactory legal protection, and underlying cultural bias against women have resulted in increasing intimate partner violence, which largely goes unaddressed, undocumented, and unreported in healthcare settings. This case study presents a common scenario of intimate partner violence and carefully analyzes its ethical implications in an emergency case at a tertiary care hospital in Karachi, Pakistan. In this study, basic ethical principles are used to discuss important ethical challenges faced daily by healthcare workers in (...) the medical, social, and legal context. It further highlights the dire need of patient education, safety, and a solid framework for addressing, documenting, and reporting intimate partner violence for healthcare workers. (shrink)

The Islamic finance industry is relatively new and vibrant. It is becoming a mainstream industry in the MENA. The industry is based on a number of Sharia’a maxims and in particular the prohibition of Riba. Islamic law scholars’ emphasis on the ethical dimension of this industry and how it can be seen as a solution to existing capitalism. The current financial crisis presented this industry with an unprecedented test and an opportunity to influence and merge into main stream finance. This (...) paper presents an evaluation of Islamic finance industry in the current financial crisis and whether the governance and ethical foundation of Islamic finance institutions distinguished itself from conventional finance. Thus, this paper begins with an overview of Islamic finance, then it discusses the governance framework structure of Islamic finance institutions and the role of its organs. In addition, this paper will compare between the ethical framework of the Islamic finance institutions and the conventional institutions. Finally, this paper will discover the ethical failure of the current global financial system and its relation with the current financial crisis. (shrink)

The Bhagavad Gita's philosophical and political significance remains forever contemporary. In this volume a group of leading historians reflect on the significance of the Bhagavad Gita for political and ethical thinking in modern India and beyond. These essays contribute new perspectives to historical, contemporary and global political ideas. Violence and nonviolence, war, sacrifice, justice, fraternity and political community were constitutive of India's political modernity, and it was to these questions that Indian public figures turned their attention in the nineteenth and (...) twentieth centuries. Oriented towards the future, these commentaries and interpretations of a text that locates war as the central problem of human life have detached the Gita from antiquity and made it foundational for India's modernity. The book would be of interest to academic researchers as well as general readers interested in South Asian history, Indian philosophy and religion. (shrink)

BackgroundTo assess ethical concerns associated with participation in a financial incentive programme to help adolescents with type 1 diabetes improve diabetes self-management.MethodsFocus groups with 46 adolescents with type 1 diabetes ages 12–17 and 38 of their parents were conducted in the Seattle, Washington metropolitan area. Semistructured focus group guides addressed ethical concerns related to the use of FI to promote change in diabetes self-management. Qualitative data were analysed and emergent themes identified.ResultsWe identified three themes related to the ethical issues adolescents (...) and parents anticipated with FI programme participation. First, FI programmes may variably change pressure and conflict in different families in ways that are not necessarily problematic. Second, the pressure to share FIs in some families and how FI payments are structured may lead to unfairness in some cases. Third, some adolescents may be likely to fabricate information in any circumstances, not simply because of FIs, but this could compromise the integrity of FI programmes relying on measures that cannot be externally verified.ConclusionsMany adolescents with type 1 diabetes and their parents see positive potential of FIs to help adolescents improve their self-management. However, ethical concerns about unfairness, potentially harmful increases in conflict/pressure and dishonesty should be addressed in the design and evaluation of FI programmes. (shrink)

Prediction of daily rainfall is important for flood forecasting, reservoir operation, and many other hydrological applications. The artificial intelligence algorithm is generally used for stochastic forecasting rainfall which is not capable to simulate unseen extreme rainfall events which become common due to climate change. A new model is developed in this study for prediction of daily rainfall for different lead times based on sea level pressure which is physically related to rainfall on land and thus able to predict unseen rainfall (...) events. Daily rainfall of east coast of Peninsular Malaysia was predicted using SLP data over the climate domain. Five advanced AI algorithms such as extreme learning machine, Bayesian regularized neural networks, Bayesian additive regression trees, extreme gradient boosting, and hybrid neural fuzzy inference system were used considering the complex relationship of rainfall with sea level pressure. Principle components of SLP domain correlated with daily rainfall were used as predictors. The results revealed that the efficacy of AI models is predicting daily rainfall one day before. The relative performance of the models revealed the higher performance of BRNN with normalized root mean square error of 0.678 compared with HNFIS, BART, xgBoost, and ELM. Visual inspection of predicted rainfall during model validation using density-scatter plot and other novel ways of visual comparison revealed the ability of BRNN to predict daily rainfall one day before reliably. (shrink)